Fluticasone furoate/fluticasone propionate - different drugs with different properties

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Fluticasone furoate/fluticasone propionate – different drugs with different properties

The similarity in the names of the recently introduced intranasal glucocorticoid fluticasone furoate (FF; Veramyst®, GlaxoSmithKline/Avamys®, GlaxoSmithKline UK, Uxbridge, UK) and the earlier fluticasone propionate (FP; Flonase®/Flixonase®, GlaxoSmithKline) has led many to assume that the two compounds have the same active principle (fluticasone) (e.g. 1, 2). This has been compounded by FP comm...

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Ng GSK Medicine: Fluticasone propionate/salmeterol, fluticasone propionate/salmeterol/norflurane

Rationale: Monitoring was required for the introduction of non-chlorofluorocarbon (CFC) propellants in metered dose inhalers (MDIs) to ensure that there were no unexpected adverse events due to the new products. A postmarketing observational study was conducted to evaluate the introduction of the MDI Seretide Evohaler TM (hydrofluoroalkane-134a inhaler containing salmeterol and fluticasone prop...

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Basal cortisol in asthmatics on two different doses of fluticasone propionate.

OBJECTIVES To evaluate basal plasma cortisol in persistent asthmatics on inhaled fluticasone propionate 200 mcg/day and 300 mcg/day. METHODS Asthma diagnosis and classification was based on Global Initiative for Asthma recommendations. Patients aged 11 years old or less received fluticasone propionate 200 mcg/day and those older than 11 years received 300 mcg/day. After 10 weeks of treatment,...

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Fluticasone propionate in Crohn's disease.

Fluticasone propionate, a topically active corticosteroid of low systemic bioavailability after oral administration, has been used in a pilot study for the treatment of mild and moderately active Crohn's disease. Twelve patients received oral fluticasone propionate for three weeks, and the effects were monitored using the Crohn's disease activity index and by 111In granulocyte scanning, assessi...

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Comparison of the effects of salmeterol/fluticasone propionate with fluticasone propionate on airway physiology in adults with mild persistent asthma

BACKGROUND This study compared the effect of inhaled fluticasone propionate (FP) with the combination of salmeterol/fluticasone propionate (SFC) on lung function parameters in patients with mild asthma. METHODS Adult patients with mild persistent asthma (> or = 80% predicted FEV1) receiving 200-500 mug of BDP or equivalent were randomised to receive either FP 100 mug or SFC 50/100 mug twice d...

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ژورنال

عنوان ژورنال: The Clinical Respiratory Journal

سال: 2011

ISSN: 1752-6981

DOI: 10.1111/j.1752-699x.2011.00244.x